The team INSERM U1149 “Role of vessels in liver diseases” investigates the link between the vessels and liver diseases. We are interested in rare vascular liver diseases (Budd-Chiari syndrome, extrahepatic vein thrombosis, and portal-sinusoidal vascular disease), but also common liver diseases including nonalcoholic steatohepatitis and cirrhosis.
In DECISION, the team will determine the composition and concentrations of a panel of extracellular vesicle subpopulations (i.e. exosomes and microvesicles) in the plasma of 1,400 patients from the PREDICT and ACLARA cohorts (currently being done for 800 patients from CANONIC). The team will use a strategy based on filtration (that provides information on size) associated with antigen detection using immunoassays. Prof. Pierre-Emmanuel Rautou, leader of the team “Roles of vessels in liver disease”, is also the coordinator of DECISION.