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News

18 June 2024

Liver International special edition on ACLF and AD: Sneak Peek #4

We’re continuing our series: Some partners of DECISION are currently preparing a special edition in Liver International on acute-on-chronic liver failure (ACLF) and acute decompensation (AD) of cirrhosis! ✨
As a sneak peek, we are excited to share some of the reviews and articles that will be cited in this special edition! (read reviews #1, #2, and #3 here)

The fourth review is:
Salvatore Piano, Nadim Mahmud, Paolo Caraceni, Marta Tonon, Rajeshwar Prosad Mookerjee: Mechanisms and treatment approaches for ACLF. Liver Int 2023

🔓https://onlinelibrary.wiley.com/doi/full/10.1111/liv.15733

🔑 Key points

  • ACLF is a life-threatening syndrome characterized by severe systemic inflammation, acute decompensation of cirrhosis and organ failures.
  • ACLF is often precipitated by intrahepatic or extrahepatic insults, such as infections, alcohol-related hepatitis or HBV flare.
  • The severe systemic inflammation, circulatory dysfunction, metabolic alterations and competition for energetic substrates contribute to the occurrence of organ failures.
  • Current management options for ACLF include: early identification and treatment of precipitants, support of each one of the organ failures and rapid assessment for the liver transplantation.
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News

11 June 2024

Liver International special edition on ACLF and AD: Sneak Peek #3

We’re continuing our series: Some partners of DECISION are currently preparing a special edition in Liver International on acute-on-chronic liver failure (ACLF) and acute decompensation (AD) of cirrhosis! ✨
As a sneak peek, we are excited to share some of the reviews and articles that will be cited in this special edition! (read reviews #1 and #2 here)

The third review is:
Ruben Hernaez, Hai Li, Richard Moreau, Minneke J. Coenraad: Definition, diagnosis and epidemiology of acute-on-chronic liver failure. Liver Int 2023

🔓https://onlinelibrary.wiley.com/doi/10.1111/liv.15670

🔑 Key points

  • Acute-on-chronic liver failure is a highly prevalent condition with high short-term mortality.
  • The presence of cirrhosis sets apart the East and the West definitions.
  • Liver failure is the organ with the highest variability in the ACLF definition.
  • Each definition can be used clinically but depends on the aim of the study.
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Events

5 - 8 June 2024

DECISION at EASL Congress 2024

What a blast! DECISION members have been super active at this year's EASL Congress 2024 in Milan, Italy. A highlight definitely was our networking event on 5th June 2024, with a packed cirrhosis and complications track hub.

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Our Vision

DECISION strives to better understand the pathophysiology of decompensated cirrhosis leading to acute-on-chronic liver failure (ACLF) at the systems level by taking advantage of already existing large and clinically well characterized patient cohorts. The ultimate goal is to significantly reduce mortality through combinatorial therapies that are tailored to the specific needs of individual patients. Part of this endeavour is to develop a reliable prognostic test and a robust response test.

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Why it matters

In 2013, cirrhosis was responsible for 1.2 million deaths worldwide. While most cirrhosis patients initially do not show symptoms, acute decompensation of cirrhosis, defined as the body’s inability to cope with the progressing dysfunctionality of the liver, leads to drastic symptoms. Decompensation is characterized by the development of ascites, hepatic encephalopathy, jaundice, or gastrointestinal haemorrhage, and is often a turning point for cirrhosis.

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