We are delighted to announce the publication of another major scientific output from the DECISION project in renowned nature communications: “Blood multiomics reveal a dysregulated lipid mediator-mitochondrial network associated with the outcome of advanced cirrhosis.”

Using integrated lipidomics, metabolomics, cytokinomics and clinical data from 766 patients with acutely decompensated cirrhosis, the study identified molecular networks associated with progression to acute-on-chronic liver failure (ACLF) and short-term mortality.
Rather than focusing on individual biomarkers, the researchers combined multiple layers of biological information to reveal how dysregulated lipid mediators, mitochondrial dysfunction and systemic inflammation are interconnected during disease progression.
Among the key findings, the study identified 20-HETE as a central regulator within the network. Laboratory experiments demonstrated that this lipid mediator promotes mitochondrial oxidative stress and impairs mitochondrial function in immune cells through a GPR75-Akt signalling pathway. Importantly, several molecular features identified in the study also showed strong potential to predict which patients are at highest risk of developing ACLF or dying in the short term.

These findings improve our understanding of the biological mechanisms underlying advanced cirrhosis while opening new avenues for biomarker development and future therapeutic strategies targeting mitochondrial dysfunction and dysregulated lipid signalling.

Congratulations to Cristina López-Vicario (FCRB), Ferran Aguilar (EF CLIF), and all authors and collaborators involved in this outstanding achievement.

We are delighted to announce the completion of the DECISION video series, a collection of short explainer videos translating key scientific findings from the project into accessible, engaging stories.

Across eight videos, DECISION researchers present important discoveries on topics ranging from immune dysfunction and epigenetic regulation to extracellular vesicles, single-cell analyses, and novel models for MASH-cirrhosis. Together, these videos offer insights into the mechanisms driving acute decompensation of cirrhosis and acute-on-chronic liver failure, while highlighting how DECISION research is contributing to improved prediction, monitoring, and treatment strategies.

Designed for clinicians, general practitioners, researchers, patients, and interested members of the public, the series aims to make complex science easier to understand without sacrificing scientific accuracy.

🎥 Watch the complete YouTube playlist.

A heartfelt thank you goes to all researchers who contributed their expertise, time, and enthusiasm to this initiative.