DECISION – DEcompensated CIrrhoSIs: identification of new cOmbiNatorial therapies based on systems approaches

News

10 September 2020

Codes of conduct applicable and research integrity policy including publications in journals published

This document is an analysis of the current codes of good conduct published by each member of the DECISION project: Here, we discuss what is included in the DECISION partners’ code of conduct, any references to national or international guidelines, how easily accessible the relevant information is from the home page and the general usefulness of the document for the members of the institutions themselves and the public.

Events

29 August 2020

1st Digital International Liver Congress (Digital ILC)

The 1st Digital International Liver Congress (Digital ILC, #ILC2020) took place from 27-29 August 2020. DECISION was represented with a virtual booth and several talks given by members.

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Our Vision

DECISION strives to better understand the pathophysiology of decompensated cirrhosis leading to acute-on-chronic liver failure (ACLF) at the systems level by taking advantage of already existing large and clinically well characterized patient cohorts. The ultimate goal is to significantly reduce mortality through combinatorial therapies that are tailored to the specific needs of individual patients. Part of this endeavour is to develop a reliable prognostic test and a robust response test.

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Why it matters

In 2013, cirrhosis was responsible for 1.2 million deaths worldwide. While most cirrhosis patients initially do not show symptoms, acute decompensation of cirrhosis, defined as the body’s inability to cope with the progressing dysfunctionality of the liver, leads to drastic symptoms. Decompensation is characterized by the development of ascites, hepatic encephalopathy, jaundice, or gastrointestinal haemorrhage, and is often a turning point for cirrhosis.