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News

17 March 2023

Watch the recording of the patient event on 6th March 2023

The event ‘The COMBAT-trial: A novel COMBinATorial therapy with albumin and enoxaparin in patients with decompensated cirrhosis at high-risk of poor outcome.’ is now available on YouTube.

Tune in as experts from DECISION explain the upcoming clinical trial or discuss the recruitment process.

Link: https://www.youtube.com/watch?v=zS3-QKd9Nlg

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Events

6 March 2023

Successful patient event on 6th March

In this event organized by ELPA with the title ‘The COMBAT-trial: A novel COMBinATorial therapy with albumin and enoxaparin in patients with decompensated cirrhosis at high-risk of poor outcome.’ experts from DECISION explained the upcoming clinical trial to patient representatives. They discussed the recruitment process and what it means from an ethical perspective. Great interest was shown in the question how patient representatives and clinicians can work together to facilitate recruitment for this trial.

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Our Vision

DECISION strives to better understand the pathophysiology of decompensated cirrhosis leading to acute-on-chronic liver failure (ACLF) at the systems level by taking advantage of already existing large and clinically well characterized patient cohorts. The ultimate goal is to significantly reduce mortality through combinatorial therapies that are tailored to the specific needs of individual patients. Part of this endeavour is to develop a reliable prognostic test and a robust response test.

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Why it matters

In 2013, cirrhosis was responsible for 1.2 million deaths worldwide. While most cirrhosis patients initially do not show symptoms, acute decompensation of cirrhosis, defined as the body’s inability to cope with the progressing dysfunctionality of the liver, leads to drastic symptoms. Decompensation is characterized by the development of ascites, hepatic encephalopathy, jaundice, or gastrointestinal haemorrhage, and is often a turning point for cirrhosis.

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