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11. August 2023

DECISION Summer reading

Here are our picks of recent liver research. With contribution by DECISION members:

1️⃣ Assessment of portal hypertension severity using machine learning models in patients with compensated cirrhosis by Jiří Reiniš, Oleksandr Petrenko et al. in Journal of Hepatology

https://www.journal-of-hepatology.eu/article/S0168-8278(22)03119-1/fulltext

2️⃣ Essential role for #albumin in preserving liver cells from TNFα-induced mitochondrial injury by Marta Duran-Güell, Glória Garrabou, Roger Flores-Costa, et al. in FASEB.

https://faseb.onlinelibrary.wiley.com/doi/10.1096/fj.202201526R

3️⃣ Management of splanchnic vein thrombosis by Laure Elkrief, Audrey Payancé, et al. in JHEP Reports.

https://www.jhep-reports.eu/article/S2589-5559(22)00239-7/fulltext

Want more scientific reading? ➡ Check out our publications page!

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Events

14 - 17 October, 2023

UEG Week 2023 – United European Gastroenterology

UEG Week 2023
14-17 October 2023, Copenhagen, Denmark

Registration still open.

DECISION coordinator Prof. Pierre-Emmanuel Rautou will be speaking about "Anticoagulation in portal vein thrombosis" during thesession "Never waste a good disaster (Hepatobiliary and pancreas)" in Auditorium 10 on Monday, October 16, 10:00 - 11:00.

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Our Vision

DECISION strives to better understand the pathophysiology of decompensated cirrhosis leading to acute-on-chronic liver failure (ACLF) at the systems level by taking advantage of already existing large and clinically well characterized patient cohorts. The ultimate goal is to significantly reduce mortality through combinatorial therapies that are tailored to the specific needs of individual patients. Part of this endeavour is to develop a reliable prognostic test and a robust response test.

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Why it matters

In 2013, cirrhosis was responsible for 1.2 million deaths worldwide. While most cirrhosis patients initially do not show symptoms, acute decompensation of cirrhosis, defined as the body’s inability to cope with the progressing dysfunctionality of the liver, leads to drastic symptoms. Decompensation is characterized by the development of ascites, hepatic encephalopathy, jaundice, or gastrointestinal haemorrhage, and is often a turning point for cirrhosis.