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DEcompensated CIrrhoSIs: identification of new cOmbiNatorial therapies based on systems approaches
News
17 June 2025
DECISION on LinkedIn: 500 Followers and Growing
We’re pleased to share that our LinkedIn community has now surpassed 500 followers! This growing network reflects the increasing interest in DECISION’s work to improve patient outcomes in decompensated cirrhosis through translational research and clinical trials.
We’re grateful for your continued support and look forward to sharing more updates, results, and opportunities for collaboration in the months ahead. 📲 https://www.linkedin.com/company/decision-project/
After an energizing few days in Amsterdam, we’re back with renewed motivation and important insights from this year’s EASL Congress 2025.
The DECISION team had the pleasure of participating in a number of sessions and meetings – from scientific presentations to networking events and our own investigator meeting. Each encounter reaffirmed the value of collaboration in tackling the complexities of decompensated cirrhosis and ACLF.
Among the highlights:
→ Our Networking Session brought together researchers, clinicians, and project partners to exchange on cutting-edge data – including biomarker discovery and single-cell sequencing.
→ The Investigator Meeting reaffirmed our shared commitment to advancing recruitment and bringing both the COMBAT and PROSPECT studies toward completion.
→ Many poster presentations!
We’re deeply grateful to everyone who engaged with us, supported our sessions, or simply stopped by to learn more about our work. Events like EASL remind us how vital community is to scientific progress.
Our 11th SC Meeting, took place on 10 April 2025 in Barcelona. These meetings are a key moment in our project timeline, an opportunity to review progress across all work packages, align on next steps, and reconnect in person.
With major updates from both clinical studies and a busy season of dissemination ahead, we had engaging discussions and shared insights that will continue to move DECISION forward.
DECISION strives to better understand the pathophysiology of decompensated cirrhosis leading to acute-on-chronic liver failure (ACLF) at the systems level by taking advantage of already existing large and clinically well characterized patient cohorts. The ultimate goal is to significantly reduce mortality through combinatorial therapies that are tailored to the specific needs of individual patients. Part of this endeavour is to develop a reliable prognostic test and a robust response test.
In 2013, cirrhosis was responsible for 1.2 million deaths worldwide. While most cirrhosis patients initially do not show symptoms, acute decompensation of cirrhosis, defined as the body’s inability to cope with the progressing dysfunctionality of the liver, leads to drastic symptoms. Decompensation is characterized by the development of ascites, hepatic encephalopathy, jaundice, or gastrointestinal haemorrhage, and is often a turning point for cirrhosis.
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