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News

24 September 2025

DECISION Masterclass: Clinical Bioinformatics – It’s More Than Pressing a Button

The latest DECISION Masterclass is now available online: Clinical Bioinformatics – It’s More Than Pressing a Button.

In this session, Dr Núria Planell Picola, Cristina Sanchez, and Dr. David Gomez-Cabrero offer a multidisciplinary view on what clinical bioinformatics truly means, within DECISION and beyond.

  • Dr Núria Planell explores the history of bioinformatics, from Mendel’s genetics to modern computational tools that turn biological data into meaningful biological insight.
  • Cristina Sanchez shares her expertise on data harmonization and integration, including the challenges of building and maintaining a high-quality, multi-cohort database for DECISION.
  • Dr David Gomez-Cabrero highlights the importance of study design in multi-omic approaches, urging researchers to ask “why” before focusing on the “how,” and demonstrating the value of iteration in clinical bioinformatics.

💡 Whether you’re new to the field or experienced in systems medicine, this Masterclass provides valuable insights into the intersection of biology, data, and clinical research in complex diseases like ACLF.

📺 Watch the full recording here.

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News

30 June 2025

Halfway There: COMBAT Hits 50% Recruitment Milestone

We’re proud to share that the COMBAT study, part of the DECISION project, has reached 50% of its recruitment target!

This marks an important moment in our shared effort to advance personalised treatment strategies for acute-on-chronic liver failure (ACLF). Every inclusion brings us closer to actionable insights that can improve patient care.

Our thanks go out to all participating clinical sites and their teams for their continued dedication, as well as to our study participants and their families.

Curious about the COMBAT trial? Our questions and answers videos are available in English, German, Italian, Spanish, and French. Check out the full playlist!

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Events

9 - 10 April 2025

11th Steering Committee Meeting

Our 11th SC Meeting, took place on 10 April 2025 in Barcelona. These meetings are a key moment in our project timeline, an opportunity to review progress across all work packages, align on next steps, and reconnect in person.

With major updates from both clinical studies and a busy season of dissemination ahead, we had engaging discussions and shared insights that will continue to move DECISION forward.

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Our Vision

DECISION strives to better understand the pathophysiology of decompensated cirrhosis leading to acute-on-chronic liver failure (ACLF) at the systems level by taking advantage of already existing large and clinically well characterized patient cohorts. The ultimate goal is to significantly reduce mortality through combinatorial therapies that are tailored to the specific needs of individual patients. Part of this endeavour is to develop a reliable prognostic test and a robust response test.

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Why it matters

In 2013, cirrhosis was responsible for 1.2 million deaths worldwide. While most cirrhosis patients initially do not show symptoms, acute decompensation of cirrhosis, defined as the body’s inability to cope with the progressing dysfunctionality of the liver, leads to drastic symptoms. Decompensation is characterized by the development of ascites, hepatic encephalopathy, jaundice, or gastrointestinal haemorrhage, and is often a turning point for cirrhosis.

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